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Methods Design and Sample We conducted eight focus groups segmented by gender and age (1824, 2535), with daily RYO smokers ( N = 50) in Greater Glasgow in Scotland between February-March 2020

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[48] Naltrexone may also initially produce opioid withdrawal-like symptoms in a small subset of people not dependent on opioids: [58] The side-effect profile [of naltrexone], at least on the recommended dose of 50 mg per day, is generally benign, although 5 to 10 percent of detoxified opioid addicts experience immediate, intolerable levels of withdrawal-like effects including agitation, anxiety, insomnia, light-headedness, sweating, dysphoria, and nausea

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It was observed that smokers have an elevated level of circulating markers of inflammation like C-reactive protein and interleukin-6 [7, 75], and also increased levels of VCAM-1 and ICAM-1, which indicates higher adhesion of immune cells to the endothelium [51]