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How to eliminate nicotine faster Once nicotine is in your system, your liver handles the breakdown into metabolites (mainly cotinine), and this process is set by your body's metabolic rate and liver function, which are then excreted by the kidneys

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Evidence suggests multiple interrelated pathways of liver injury: Nicotine-induced injury : Nicotine is metabolized in the liver via CYP2A6, where it activates 7-nicotinic acetylcholine receptors (7-nAChR), leading to oxidative stress, mitochondrial dysfunction, and pro-fibrotic signaling [36, 125, 126]

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