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Solving this problem has been a challenge for the research community because many of the metals found in tobacco smoke could also come from industrial or naturally occurring pollutants contaminating indoor and outdoor air

The reduction in smoking rates in Korea reflects the impact of expanded tobacco control policies and public health initiatives

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These cellular dysfunctions, including mitochondrial dysfunction and endoplasmic reticulum stress, can initiate a cascade of events, including oxidative damage, inflammation, and neuronal death, which are hallmark features of ALS pathology 24