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And, she added, most addiction to tobacco begins in adolescence

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Bibcode:1983PNAS...80.4803F

While human extract catalyzed N-methylation of both forms of nicotine, rat extract did not form any N-methylation products, and guinea pig extract only transformed R -nicotine, but not S -nicotine (63)

Determination of nonvolatile organic acids in tobacco samples by ultra-high performance liquid chromatography (UPLC)