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Furthermore, MMPs contribute to CVDs and cancers by degenerating extracellular matrix and mediating inflammation through post-translational processing of inflammatory cytokines, chemokines, cell adhesion molecules, and their receptors on cells [18, 42]
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even one or two puffs can prime the nervous system (nicotine), vasculature (CO and oxidative stress), and airway defenses (acrolein) in a way that increases cravings and lowers comfort thresholds
Therefore, while we were unable to calculate confidence intervals on our estimates we have tried to be conservative with our assumptions
