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In all of the analyses, 2-tailed p-values less than .05 were considered statistically significant

However, this research has limitations: It used lower nicotine concentrations than many modern products The study was relatively small and focused on rectal tone specifically It didn't account for higher-strength products like 6mg ZYN pouches Higher-strength products like 6mg or 9mg ZYN pouches contain substantially more nicotine and may produce stronger digestive responses

Centers for Disease Control and Prevention, 2004)

Smoking cigarettes is a habitual behaviour for many, and some are in such advanced stages of smoking that they find it difficult to let go of the habit even if they want to

adult cigarette consumption, according to data from the National Health Interview Survey, 2017