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All studies that reported an increased risk of cancer assessed acute exposure effects to e-cigarettes (Figure 3)

IBvape owners traveling abroad should verify whether local law treats nicotine-containing e-liquids as pharmaceuticals, which may affect permitted volumes or documentation

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Both alcohol and tobacco smoke induce certain cytochrome P450 enzymesparticularly CYP2E1 (by ethanol) and CYP1A2 (by tobacco smoke)which can lead to altered drug metabolism and increased production of toxic intermediates

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