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Details on how these statistically significant estimates were applied to each WHO sub-region can be found in web Additional file 1: Appendix 4

This helps explain why some individuals experience a sense of calm or improved mental clarity with nicotine use, since stress perception and inflammatory tone are deeply intertwined

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A meta-analysis of 19 studies found that providing smoking cessation interventions during addictions treatment was associated with a 25% greater likelihood of long-term abstinence from alcohol and illicit drugs