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Cytoplasmic ROS (H 2 O 2 ) have been observed to activate NF-B via oxidation and activation of IKK, whereas nuclear ROS (H 2 O 2 ) have been observed to inhibit the binding of NF-B to DNA via oxidation of cysteine residues, thereby decreasing its transcriptional activity (Nakajima and Kitamura, 2013)

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(Photo by SSPL/Getty Images) (SSPL via Getty Images)11 / 13Joe DiMaggioNBC SPORTS -- "Joe DiMaggio Interview" -- Pictured: (l-r center) NBC Sports' Joe Garagiola, Baseball Hall of Famer Joe DiMaggio during an interview on April 4, 1963 -- Photo by: Bob Manker/NBC/NBCU Photo Bank (NBCUniversal via Getty Images)12 / 13Arnold PalmePro Golfer Arnold Palmer smoking on green while crowd watches