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Ethnobotanical finds and oral traditions indicate that various forms of tobacco, particularly Nicotiana tabacum, were used in spiritual and ceremonial contexts in the Andean regions of Bolivia and northwestern Argentina as early as 5,500 years ago

Decreased Immune Function : Immune suppression : Smoking weakens the immune system, reducing the bodys ability to fight off infections that might develop if a leak occurs

In 10th and 12th grades, the annual increases are the largest ever recorded for any substance in the 44 years that MTF has tracked adolescent drug use

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