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Description
CS consists of two phases: the tar phase containing nicotine, the addictive substance of CS, and the gas phase
Evaluation of lungs from patients with COPD finds the predominant histologic and molecular changes to occur within bronchial epithelial cells 2
Recent studies have indicated that there is a strong coincidence of G to T transversion hotspots in lung cancers and sites of preferential formation of PAH adducts along the p53 gene

Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway

Gain-of-function mutant p53 in cancer progression and therapy
