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Further high-quality, randomized controlled trials and rigorous observational studies are important to confirm findings from the research to date

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Although RCTs are required to determine the effectiveness or safety of nicotine products as smoking cessation tools, outcomes related to latency, such as oral cancer, require long-term observational studies

the Australian NHMRC (241944, 339462, 389927, 389875, 389891, 389892, 389938, 442915, 442981, 496739, 552485 and 552498) and the Australian Research Council (A7960034, A79906588, A79801419, DP0770096, DP0212016 and DP0343921)