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Not all drugs can be smoked, for example the sulphate derivative that is most commonly inhaled through the nose, though purer free base forms of substances can, but often require considerable skill in administering the drug properly

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Support for e-cigarettes as efficacious cessation tools consists of very few randomized controlled clinical trials, and thus more work is needed to establish the extent to which e-cigarettes with a proven nicotine delivery profile can play a role in helping smokers quit

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Oxidative damage from smoking can also be combated by antioxidant-fortified balms or serums