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[35] [36] A 2025 study that analyzed data from the National Vital Statistics System (NVSS), the Behavioral Risk Factor Surveillance System (BRFSS), the National Health Interview Survey (NHIS), and the National Survey on Drug Use and Health (NSDUH) concluded that e-cigarettes had preserved 677,000 lifeyears from 2011 to 2019

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We think that while it is clear that different endpoints may yield quite different results, the human MOE for cannabis based on the endpoint psychotropic effects can be seen as general validation of the MOE concept, because the resulting values below 1 are expected as the psychotropic effect is the desired endpoint (and hence the psychotropic threshold dose is exceeded by drug users)

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