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Future research through large-scale, multiethnic longitudinal studies and clinical trials is crucial to establish a cause-and-effect relationship, provide conclusive insights into genetic factors, and fully understand the impact of smoking on prostate cancer biology, potentially revealing therapeutic targets and fully understand the effects of smoking on prostate cancer biology, potentially revealing therapeutic targets

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However, this approach can suffer from publication bias (studies with more positive findings are more likely to be published), language bias (studies published in non-English language are not included), database bias (articles not indexed in Medline, Embase, and Scopus are not included), and time-lag bias (articles in press or published after the completion of the search were not included), which are general limitations to most literature reviews