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Writing in the December 2020 edition of the American Journal of Preventive Medicine , Oliver and Foulds noted that cigarette smoking remained a major cause of premature death and nicotine dependence was a major barrier to smoking cessation, (Association Between Cigarette Smoking Frequency and Tobacco Use Disorder in US Adults)

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Lopez-Guisa JM, Powers C, File D, Cochrane E, Jimenez N, Debley JS

106.Chung KT

Post-acute withdrawal syndrome extends neurobiological vulnerability for opioids, benzodiazepines, and alcohol for 6 to 24 months beyond acute detox through persistent mood dysregulation and cravings linked to incomplete receptor resensitization