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Adenosine normally dampens dopamine signalling caffeine's blockade removes this dampening, leaving nicotine's dopamine release unattenuated

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[DOI] [PubMed] [Google Scholar] 23.Oliveira H, Span M, Santos C, Pereira Mde L

The isolated biphenyl compounds demonstrated moderate cytotoxic activities against these human tumor cell lines, with IC50 values ranging from 2.8 to 9.4 M [79]