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To ensure the accuracy of the nicotine concentrations that were measured, we used high-resolution mass spectrometry that can differentiate molecules that are as small as 0.001 Da

[55] tested the lung tissues of ten patients with COPD and ten normal subjects, respectively, and found that Notch1 was mainly expressed in endothelial cells, and was significantly decreased in the endothelial cells of patients with COPD

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