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It reverses or halts the effects of the work that has been done to improve health care in these countries, and although smoking is deemed as a "voluntary" health risk, the marketing of tobacco towards very impressionable adolescents in the developing world makes it less of a voluntary action and more of an inevitable shift

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More serious are the systemic effects of nicotine intoxication : dizziness and nausea

PDEA further claimed that its laboratory findings on tuklaw show not only nicotine but also a synthetic cannabinoid which is designed to mimic the effects of marijuana but [is] more potent and dangerous. According to the two agencies, tuklaw may cause psychotic episodes and hallucinations as well as seizure-like symptoms characterized by brief, shock-like body jerks and twitches. These deadly cigarettes laced with synthetic cannabinoid are obviously smuggled goods and reportedly sold online, PDEA Director General Isagani Nerez said in the statement

[63] [64] The most important chemicals causing cancer are those that produce DNA damage since such damage appears to be the primary underlying cause of cancer