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Role of human cytochrome P4502A6 in C-oxidation of nicotine

The dark, unfiltered style these brands made famous produces a heavier, more robust smoke than the blond-tobacco cigarettes common in North America
Reduced exposure, however, does not necessarily assure reduced risk to the user or reduced harm to the population

doi:10.1097/ADM.0000000000000083 Khan JS, Hah JM, Mackey SC

This type of headache affects men more frequently