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Vape liquids usually incorporate: Nicotine (the main psychoactive drug in tobacco) Potentially, other drugs (e.g

Yet many people successfully use tapering methods, such as nicotine, gum, patches, and nasal sprays

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For dose-response assessment, if clinical or epidemiological data are not available, extrapolation from high-to-low-dose exposures and from animal to human doses in dose-response assessment is required

Randomization After the 2-week run-in phase, stage 2 will be initiated, in which participants who fail to achieve 7-day abstinence (self-report of not smoking for at least the past 7 days at week 3 study visit) will be randomly assigned to the experimental (group A, escalating active patches) or a control condition (group B, escalating placebo patches) for 10 additional weeks of treatment