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Description
Through the secretion of COX-2, prostaglandin E2, VEGF, and ERK, as well as the activation of ERK and a COX-2-dependent rise in VEGF and VEGF receptor, nicotine promotes the development and relocation of gastric cancer cells

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And there are lots of harder questions that remain unanswered, as the American Thoracic Society has noted

Other limitations include methodological inconsistencies in the studies included in this review

That is not a coincidence
