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Description
Nicotine whether delivered through cigarettes, e-cigarettes, pouches, gum, or patches has real, documented effects on the skin that can contribute to acne

More recently, we could show that cigarette smoking extract, aqueous smoke extracts of a heated tobacco product, an electronic cigarette, a conventional cigarette (3R4F), and pure nicotine activated anti-oxidative and pro-inflammatory processes in human monocytes [32]

The most brutal example of this is when the two play "House" together
[PubMed] [Google Scholar] 48.Pamuk ON, Donmez S, Cakir N

In addition to addiction, chronic nicotine use has been linked to cardiovascular, respiratory, pulmonary, and gastrointestinal disorders
