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See Supplementary Table 9 for more details on included observations from each study (n = 50 studies)

Otherwise, a crude or adjusted summary statistic and standard error (SE) or upper and lower bound of 95% confidence interval (CI) were extracted

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4 CONCLUSION A shared decision-making discussion with the pregnant patient about the risks and benefits of pharmacologic treatments used to help with quitting and the risks of continued tobacco or nicotine use is necessary, and treatment must be done under close supervision or referral to specialty care