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For example, PAHDNA adducts are observed in lung tissues, and p53 tumor suppressor mutations in lung tumors resemble the damage created by PAH diol epoxide metabolites in vitro

Contributors The PATH Study is a large and complex study with integral input provided for the planning, conduct and reporting of the study from each author as noted below

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Review/Action The substantive review phase (Phase 3) includes evaluation of the scientific information and data in an application