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Importantly, higher levels of cotinine, a major nicotine metabolite, were observed in female mice compared to male mice in our experiments

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An early randomised controlled trial also found that e-cigarettes were as ineffective as nicotine replacement therapy in cessation at six months follow-up: 92.7% e-cigarette users still smoking compare with 94.2% using nicotine patches
Inhale to Ignite : Draw in gently to light the cigarette

Varenicline Varenicline is a nicotinic receptor partial agonist, which acts centrally to relieve cravings and withdrawal symptoms as well as reducing the rewarding effect of smoking
