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Instead, the main goal of treatment is to prevent or slow down further damage by managing risk factors

Pain manifestations are widespread and involve the musculoskeletal system, as well as the nervous system and internal organs (Table 6) [19, 47, 53, 54, 67, 75, 84, 8693]

When nicotine pouches first entered the market, they occupied a regulatory gray zone, especially those made with synthetic nicotine, a lab-created form not derived from the tobacco plant

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