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substance misuse can disrupt the delicate balance of chemicals in the brain, leading to changes in mood, cognition, and behavior
Campaign for Tobacco-Free Kids, Broken Promises to Our Children: a State-by-State Look at the 1998 State Tobacco Settlement 19 Years Later FY2018, 2017

According to Anstey, K

The home environment, especially during childhood, is a very important factor

They may feel invisible, unheard and powerless