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Acknowledgements None Abbreviations BDNF Brain-derived neutrophic factor CAD Coronary artery disease CEA Carcinoembryonic antigen CO Carbon monoxide DNA Deoxyribonucleic acid ENDS Electronic nicotine delivery systems EPA Environmental Protection Agency FDA Food and Drug Administration FEF Forced expiratory flow FeNO Fractional exhaled nitric oxide FEV Forced expiratory volume FMD Flow-mediated dilation FVC Forced vital capacity GSH Glutathione HR Heart rate IHD Ischemic heart disease IL Interleukin MI Myocardial infarction mRNA Messenger RNA NO Nitric oxide PAHs Polycyclic aromatic hydrocarbons RNA Ribonucleic acid ROS Reactive oxygen species TNF Tumor necrosis factor TXB 2 Thromboxane B 2 VEGF Vascular endothelium growth factor Authors contributions HQ wrote the manuscript and prepared the figure

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This will include considering information we gather from consultation responses and any new data and evidence made available since the impact assessments were completed