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The results suggested that estrogen activation of olfactomedinswhich is suppressed when nicotine is presentmight serve as a feedback loop for driving nicotine addiction processes by activating areas of the brains reward circuitry such as the nucleus accumbens

The ARIC investigators

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One of the problems seen by sociologists and medical researchers is that marketing of tobacco products seems to be more pervasive in disadvantaged neighborhoods, where cigarettes are more likely to be more affordable