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[45] found that e-cigs have a powerful booster effect on phase-I carcinogen-bioactivating enzymes, including activators of polycyclic aromatic hydrocarbons (PAHs), and increase oxygen free radical production and DNA oxidation to 8-hydroxy2'-deoxyguanosine

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plump up the skin around the mouth, thereby reducing the appearance of wrinkles (11)

Tobacco abuse liability is increased by the presence of pyrazines, which can compensate for the poor reinforcing effects of nicotine alone by acting on central nervous system receptors and enhancing the addictive potential of cigarettes

Aside from Trading Standards, the big tobacco firms also carry out their own investigations into, and prosecutions of, black market sales