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Indigenous Origins: The Sacred Smoke Long before tobacco became a global commodity, it held deep cultural and spiritual significance for Indigenous peoples of the Americas

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Heavy nicotine use More severe poisoning can lead to: lowered blood pressure lowered heart rate fatigue weakness While rare in adults, extreme poisoning can cause: seizures coma difficulty breathing respiratory failure How do nicotine patches work

Pulmonary physiology is also affected by e-cigarette aerosol inhalation, with increased airway reactivity, airway obstruction, inflammation and emphysema

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