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From a vascular perspective, smoking exerts both acute and chronic effects on endothelial function, which may influence the pathophysiology of UC
This results in a slower-burning cigarette
rather, MAO inhibition needs to be more chronic, persisting for a week or more (Smith et al., 2015, 2016), which means that the effect of MAO inhibition of nicotine self-administration is not a direct effect of MAO inhibition per se , but additionally requires some chronic adaptation to MAO inhibition
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