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The whole system is engineered to keep the temperature well below the 600C point where tobacco starts to burn

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In contrast, while CS extract reduced epithelial barrier integrity (determined by the translocation of dextran from the apical to the basolateral side of the cell layer), e-cigarette aerosol did not, suggesting that only CS extract negatively affected host defence [28]

What isn't in doubt is that even the small amount of nicotine found in e-cigarettes has negative effects

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