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Excess cytoplasmic residues of round spermatids are phagocytosed by Sertoli cells leaving a small cytoplasmic droplet for osmotic balance and final tail elongation during epididymal transit.[31] Epididymal dysfunction due to tobacco chewing may be a direct cause of retaining cytoplasmic residues, by preventing the timely loss of droplet and the development of secondary abnormalities in sperms