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Cigarette smoke extract mediates cytotoxic effects on human endothelial cells by reducing cell viability and inducing markers of apoptosis like cleaved caspase-3 and necrosis [63]

73 The US Public Health Service Treating Tobacco Use and Dependence guideline provides evidence-based recommendations for tobacco dependence treatment

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We share a similar view and will make the case that Australias current approach to nicotine control has facilitated the very conditions that have enabled the black market to thrive, thereby creating new social and economic harms in addition to its suboptimal effectiveness in reducing harms from tobacco alone

[DOI] [PMC free article] [PubMed] [Google Scholar] 24.Joseph AM, Norman SM, Ferry LH, Prochazka AV, Westman EC, Steele BG, et al