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Systemic reactions may start mild, but they can quickly turn life-threatening

Behavioral depression produced by an uncontrollable stressor: Relationship to norepinephrine, dopamine, and serotonin levels in various regions of rat brain

Nicotine mimics a chemical, acetylcholine, which is naturally produced in the body and is responsible for stimulating nerves

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The net cash flows relating to the adjusting items within profit from operations on pages 31 to 35, included in the above, are an outflow of 156 million (31 December 2022: 466 million outflow)