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Description
The FDA review paints a mixed picture of the potential benefits of the iQOS "heat-not-burn" approach

Key facts: In 2022, tobacco-smoking caused over 3,750 cases of cancer (or 14.7% of all invasive cancers (excluding non-melanoma skin cancers))
Further, the co-expression of PD-1 and T-cell immunoglobulin and mucin domain-containing molecule-3 (TIM-3) on CD8 + T cells increases with COPD severity (143)

Reynolds Tobacco Company from Wachovia in 1920
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