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The mechanisms that lead to Th2 polarization are not yet completely understood, but recent findings highlighted that DCs conditioned by epithelial cell-derived alarmins (TSLP, IL-25, and IL-33) generate less production of IL-12 and increase the expression of costimulatory molecules such as OXO40L or Notch receptor ligands because positive feedback skews CD4 + T cells toward Th2 polarization [162, 215, 219]

[DOI] [PMC free article] [PubMed] [Google Scholar] 43.De Jong K., Vonk J.M., Imboden M., Lahousse L., Hofman A., Brusselle G.G., Probst-Hensch N.M., Postma D.S., Boezen H.M