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Cochrane review of a total 101,804 participants showed that NRT, bupropion and varenicline are superior to placebo, all forms of NRT are effective and varenicline is superior to bupropion with odds ratio OR 1.59 (95% CI 1.29 to 1.96) and to single type of NRT with OR 1.57 (95% CI 1.22 to 1.87) but not combination of NRT with OR 1.06 (95% CI 0.75 to1.48) [69]

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Compared to vertebrates, they are inexpensive, have short generation times, can be kept in large population sizes, and raise fewer ethical issues