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Lab studies have documented some potentially toxic constituents in some devices, e-liquids, and flavors, especially when overheated to produce aldehydes (such as acrolein and formaldehyde) and an acrid dry puff condition unlikely to be tolerated by actual users (31)

29 found the mobility CMD of fresh tobacco smoke varied between 170 and 290 nm with the CMD decreasing with increasing puff number, higher puff inhalation rates, or lower cigarette ventilation