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Tsunoda K, Ohta Y, Shinogami M, Soda Y (1995) Does passive smoking affect the incidence of nasal allergies

As users become more tolerant to nicotine, they require higher doses to enjoy the same effects

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It also created a process for the FDA to evaluate requests from companies seeking to market their products as modified risk. Under the FD&C Act, a modified-risk tobacco product (MRTP) is any tobacco product that is sold or distributed for use to reduce harm or the risk of tobacco-related disease associated with commercially marketed tobacco products. This includes products, the label, labeling or advertising of which represents implicitly or explicitly that the product or its smoke does not contain or is free of a substance and/or that the product presents a lower risk of tobacco-related disease or is less harmful than one or more other commercially marketed tobacco products