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(This exponential approximation is of adequate accuracy for each age range up to and including 90-94 years.) When survival curves of smokers and non-smokers (or of smokers, non-smokers, and ex-smokers) are to be compared to assess the effects of tobacco, they have to be standardised for calendar year

Adolescents who metabolize nicotine normally have been found to progress to nicotine dependence more quickly than those with gene variants associated with slow metabolism (Audrain-McGovern et al

Its the ingredient that causes dependence and makes tobacco harder to quit

Conclusion: Cotinine After One CigaretteWhy It Matters Even one cigarette can create measurable cotinine levels in urine , blood , and saliva

doi: 10.1038/clpt.2009.19