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With thousands of devices, even more types of liquid used in the devices and many ways to use e-cigarettes, research on what problems the products cause is complicated

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To remain on the market, companies generally must show that their products will reduce disease among adult tobacco users without attracting teens and adolescents

for example, the CHRNA5-A3-B4 gene cluster is associated with smoking quantity and tobacco dependence 165,166 and has been used in a number of MR studies