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However, the long-term cost of smoking can add up quickly

First, while the current design allowed us to focus on a precise period of abstinence (1220 h) and apply a rigorous counterbalanced within-participant design in non-treatment-seeking smokers, we cannot extrapolate these results to longer periods of abstinence and naturalistic conditions of smoking cessation

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In rare instances, mixing alcohol with antidepressants may trigger pathological intoxication, where the individual experiences significant alcohol-induced impairment, possibly becoming violently disinhibited