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This decrease is believed to be caused by the harmful chemicals present in cigarettes, such as nicotine and carbon monoxide
This is why the association of smoking and schizophrenia shows up at gene level

Heavy drinking is clearly associated with heart muscle damage (cardiomyopathy), arrhythmias, and a greater risk of cardiovascular disease

Whereas the hidden damage that happens within the brain is not often apparent until its too late

What can we DO about it