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The narrow fitted sleeve of the 1840s began to loosen at the end of the decade, and in the 1850s, sleeves became wide and open, expanding from either the shoulder or the elbow

I just had this burning desire to create something that felt like straight-up magic

For example, aromatic anticonvulsants are metabolized by CYP (cytochrome P450 - phase I of drug metabolism) into arene-oxide metabolites, normally detoxified in the conjugation pathways (phase II of drug metabolism) into inactive metabolites by epoxide hydrolase or glutathione transferase

The example of brown shoes and black trousers is a strange one as well of course its different

The big gap of bare leg allows the leg to look elongated and not stumpy