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This can be due to a number of reasons, such as a lack of B12 in the diet, reduced stomach acidity, or when particular cells in the stomach - the "parietal" cells - do not produce enough intrinsic factor

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Association between biological immunotherapy for psoriasis and time to incident inflammatory arthritis: a retrospective cohort study

PMCID: PMC280272

However, although we think deeply towards the refinement of current approaches and techniques, as well as towards the potential for discovering future applications, we draw heavily upon the pioneering discoveries of functional neurosurgery and the initial findings of deep brain stimulation (DBS)