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Oxidative stress related to iron overload markedly increases malondialdehyde, a marker of lipid peroxidation [85], and high levels of myeloperoxidase released by activated leukocytes and neutrophils, causing endothelial dysfunction and liver injury [86]

These approaches measure effects across a range of biological pathways simultaneously and can be used to investigate a chemicals mode of action, predict toxicological effects, characterize dose response relationships, and understand species relevance

Mol Psychiatry 17:389401

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Second, targeting ferroptosis in lung cancer cells while safeguarding normal cells represents a pressing technical challenge that necessitates urgent resolution