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Vitamin C pairing prevents glutathione oxidation and maximizes cellular benefits

The PI3K/AKT/mTOR signaling pathway has been demonstrated to be the most disturbed pathway in ovarian granulosa cells (GCs) under oxidative stress and in PCOS ( 2 O 2 -induced GCs and a PCOS rat model (Xu et al., 2022)

Additionally, while some may tolerate a high amount of caffeine, many will experience side effects, including hormone changes and sleep disturbance

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This overexposure pattern depletes intracellular antioxidants, disrupts redox balance and leads to adverse effects, including cell apoptosis, proliferation inhibition, and functional impairment